Uptake of free choline by isolated perfused rat liver.

نویسندگان

  • S H Zeisel
  • D L Story
  • R J Wurtman
  • H Brunengraber
چکیده

The uptake of free choline by isolated perfused rat liver was characterized. A saturable uptake mechanism [Ka = 0.17 +/- 0.07 mM (SD); Vmax = 0.84 +/- 0.16 mumol/min X g dry weight] and a nonsaturable mechanism (through which uptake is proportional to choline concentration in the perfusate) were identified. Most of the choline transported into hepatocytes was converted to betaine, phosphorylcholine, or lecithin. Free choline also accumulated within the intracellular space, suggesting that choline oxidase activity does not always limit choline's uptake by the liver.

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عنوان ژورنال:
  • Proceedings of the National Academy of Sciences of the United States of America

دوره 77 8  شماره 

صفحات  -

تاریخ انتشار 1980